Multiple Site-Specific in Vitro Labeling of Single-Chain Antibody
نویسندگان
چکیده
منابع مشابه
Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.
A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility of the approach was demonstrated by conjugating independently three different...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2009
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc900149r